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Viktigste artikler om Multaq

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  • Oppdatert : 2018-03-05

Felleskatalogtekst for Multaq

Multaq SPC (Summary of Product Characteristics)

ATHENA-studien

Hovedpublikasjonen
Hohnloser SH, Crijns H, Eickels M et al.
Effect of Dronedarone on Cardiovascular Events in Atrial Fibrillation. N Engl J Med 2009;360:668-78

Publikasjoner fra substudier

ATHENA og reduksjon i slagrisiko
Connolly S, Crijns H, Torp-Pedersen C et al.
Analysis of Stroke in ATHENA: A Placebo-Controlled, Double-Blind, Parallel-Arm Trial to Assess the Efficacy of Dronedarone 400 mg BID for the Prevention of Cardiovascular Hospitalization or Death From Any Cause in Patients With Atrial Fibrillation/Atrial Flutter. Circulation. 2009;120:1174-1180

ATHENA og lone AF
Duray GZ, Torp-Pedersen C, Connolly S et al.
Effects of Dronedarone on Clinical Outcomes in Patients with Lone Atrial Fibrillation: Pooled Post Hoc Analysis from the ATHENA/EURIDIS/ADONIS Studies Journal of Cardiovascular Electrophysiology 2011, 22:7

Symptomlindring

EURIDIS/ADONIS-studien
Singh BN, Connoly S, Harry J et al.
Dronedarone for Maintenance of Sinus Rhythm in Atrial Fibrillation or Flutter. N Engl J Med 2007;357.987-99

DIONYSIS-studien - Multaq vs. amiodaron
Heuzey J, Ferrarii G, Radzik D et al.
A Short-Term, Randomized, Double-Blind, Parallel-Group Study to Evaluate the Efficacy and Safety of Dronedarone versus Amiodarone in Patients with Persistent Atrial Fibrillation: The DIONYSOS Study J Cardiovasc Electrophysiol 2010, Vol. 21, pp. 597-605

Andre studier og artikler

DAFNE-studien - dose/effekt
Touboul P, Brugada J, Capucci A et al.
Dronedarone for prevention of atrial fibrillation: A dose-ranging study. European Heart Journal (2003) 24, 1481–1487

ANDROMEDA-studien - hjertesvikt
Køber L, Torp-Pedersen C, McMurray J et al.
Increased Mortality after Dronedarone Therapy for Severe Heart Failure. N Engl J Med 2008;358:2678-87

ERATO-studien - permanent AF
Davy J, Herold M, Hoglund C et al.
Dronedarone for the control of ventricular rate in permanent atrial fibrillation: The Efficacy and safety of dRonedArone for The Control of ventricular rate during atrial fibrillation (ERATO) study. Am Heart J 2008;156:527.e1-527.e9

NB! Multaq er kontraindisert hos pasienter med permanent AF.

PALLAS-studien - permanent AF
Connolly SJ, Camm AJ, Halperin JL, et al.
Dronedarone in high-risk permanent atrial fibrillation. N Engl J Med 2011. DOI: 10.1056/NEJMoa1109867

NB! Multaq er kontraindisert hos pasienter med permanent AF.